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KoVidone® K

Trade name: KoVidone® K

Trade name：KoVidone ^®K

INCI Name：PVP（Polyvinylpyrrolidone）

Chemical description： Polyvinylpyrrolidone

Monomer molar mass： 111.14g/mol

CAS-No. : 9003-39-8

KoVidone® K

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产品详情

Properties:

Easily soluble in water and most organic solvents, even at high concentrations, it can form a clear and transparent solution. The aqueous solution is nonionic and does not require neutralization. It can be used as a stabilizer for emulsions, dispersions, and suspensions. It is compatible with most inorganic salts, resins, and the majority of excipients. The film formed from its aqueous solution has high hygroscopicity and adhesiveness. Tablets formed with PVP dissolve quickly in the digestive tract, causing the tablets to expand locally and disintegrate, releasing drug fragments, which in turn accelerates the dissolution and absorption of the medication, playing a role in rapidly exerting the drug's effect. PVP is widely used in pharmaceutical tablets and granules.

产品规格：

Product	Status	Mw	K Value	Applications
KoVidone^®K12	Powder	3,000 - 7,000	10.2 - 13.8	As a solubilizer, dispersant, and crystal growth inhibitor in liquid formulations, and as a solubilizing carrier material in solid dosage forms.
KoVidone^®K15	Powder	8,000 - 12,000	12.75 - 17.25
KoVidone^®K17	Powder	10,000 - 16,000	15.3 - 18.36
KoVidone^®K25	Powder	30,000 - 40,000	22.5 - 27.0	Used as an adhesive, film-former, solubilizer, suspension stabilizer, and dispersing agent, it is commonly applied in both solid and liquid pharmaceutical formulations.
KoVidone^®K30	Powder	45,000 - 58,000	27 - 32.4
KoVidone^®K60	Powder	270,000 - 400,000	54 - 64.8	As a binder, thickener, suspending stabilizer, applied in solid and liquid formulations.。
KoVidone^®K90	Powder	1,000,000 - - 1,500,000	81 - 97.2

Note: 1) The K value is obtained by converting the kinematic viscosity of a 1% aqueous solution and calculating the viscosity average molecular weight according to the Mark Houwink formula.

Applications：

Function	Main applications
Binder	Preferred binder for solid dosage forms, suitable for wet granulation, dry granulation, direct compression, and fluidized bed granulation. Particularly suitable for rapid-release formulations and anhydrous processes, as well as for drugs with poor water solubility, sensitivity to water, and poor compressibility. It effectively improves the compressibility of granules, enhances the binding and hardness of tablets, and promotes drug release.
Solubilizer	Enhance the solubility of poorly soluble drug formulations and improve bioavailability.
Dispersing or co-grinding agent.	As a solid dispersion carrier for the solubilization of poorly soluble drugs, forming co-precipitates or co-ground solid dispersions with poorly soluble drugs.
Active ingredient stabilizer.	Forming amorphous dispersed complexes with the drug to enhance drug stability.
Suspending agent.	Enhancing the suspension stability of oral liquid formulations.
Coating film-forming agent	Coating material auxiliary film-former and pore-forming agent, and pigment dispersant; reducing the viscosity of the coating solution, enhancing the flexibility of the film and the binding ability to the surface of the tablet core, improving the dispersibility and extensibility of lake pigments and light-blocking agents.
Crystallization inhibitor and thickening agent.	Used as a viscosity regulator in liquid formulations and as a solubilizing stabilizer for drugs; extends the duration of drug action and provides lubrication.
Pore-forming agent.	Used in sustained-release and taste-masking solid dosage forms to create water-soluble channels, regulating the dissolution rate and release rate of the drug.
Others	Capsule flow aid; stabilizer for enzymes and heat-sensitive drugs; moisturizing, thickening, and film-forming agent for topical formulations; various foods and health supplements.