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OraRez® MS

Trade name: OraRez® MS

Trade Name：OraRez^® MS

Chemical description：Mixed calcium/sodium salt of methyl vinyl ether-co-maleic acid copolymer

CAS-No. : 62386-95-2

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Product Details

Properties:

Water soluble polymer; Excellent wet adhesive strength; Strong cohesive forces due to calcium bridges; Excellent mucosal adhesive; Highly viscous aqueous solutions; Low toxicity.

Specification:

OraRez^® MS	Specification
Appearance	Free flowing white or off-white powder
pH(1% in water solution）	6.0~7.0
Moisture（%max)	10
Calcium（%）	11~16
Tap density（g/cm3)	≥ 0.5
Total bacteria count（CFU/g)	≤ 500
Yeast/mold (CFU/g)	≤ 200
E.coli（CFU/g)	Negative
Staphylococcus aureus（CFU/g)	Negative
Salmonella（CFU/g)	Negative

Applications:

1 Oral preparations: denture adhesives, ulcer patches and periodontal gels, delivering prolonged mucoadhesion to enhance local therapeutic efficacy in the oral cavity.

2 Oral films: film-forming agent for orodispersible films and orally disintegrating tablets, with an additional function of stabilizing active pharmaceutical ingredients.

3 Mucosal gels: sustained-release formulations for nasal and vaginal administration that reduce liquid runoff and extend the duration of therapeutic action.

4 Transdermal preparations: base material for microneedles and topical analgesic patches to facilitate skin permeation of drugs.

5 Nano drug delivery: coating carrier for poorly soluble drugs and herbal extracts to improve dissolution rate and colloidal stability.

6 Medical dressings: matrix for antibacterial wound hydrogels that moisturize tissues, accelerate healing and avoid adhesion to wounds.

7 General pharmaceutical excipients: thickener for gels and suspensions, chelating stabilizer for metal ions, extending the shelf life of finished formulations.

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